Delphinidin attenuates pathological cardiac hypertrophy via the AMPK/NOX/MAPK signaling pathway
Youming Chen, Zhuowang Ge, Shixing Huang, Lei Zhou, Changlin Zhai, Yuhan Chen, Qiuyue Hu, Wei Cao, Yuteng Weng, Yanyan Li
Abstract
. In addition, excessive levels of ERK1/2, P38 and JNK1/2 phosphorylation induced by oxidative stress were abrogated by delphinidin. Delphinidin was conclusively shown to repress pathological cardiac hypertrophy by modulating oxidative stress through the AMPK/NADPH oxidase (NOX)/mitogen-activated protein kinase (MAPK) signaling pathway.
Topics & Concepts
DelphinidinInternal medicineAMPKNADPH oxidaseMuscle hypertrophyOxidative stressEndocrinologyMedicinePhosphorylationMAPK/ERK pathwayReactive oxygen speciesProtein kinase ACell biologyChemistryBiologyBiochemistryCyanidinAntioxidantCardiac Fibrosis and RemodelingNitric Oxide and Endothelin EffectsCardiovascular Function and Risk Factors