The eIF2α kinase HRI triggers the autophagic clearance of cytosolic protein aggregates
Tapas Mukherjee, Valeria Ramaglia, Mena Abdel‐Nour, Athanasia A. Bianchi, Jessica Tsalikis, Hien N. Chau, Suneil K. Kalia, Lorraine V. Kalia, Jane-Jane Chen, Damien Arnoult, Jennifer L. Gommerman, Dana J. Philpott, Stephen E. Girardin
Abstract
mice showed accumulation of misfolded α-synuclein in the lateral collateral pathway, a region of the sacral spinal cord horn that receives visceral sensory afferents from the bladder and distal colon, a pathological feature common to α-synucleinopathies in humans. Together, these results suggest that HRI contributes to a general cytosolic unfolded protein response that could be leveraged to bolster the clearance of cytotoxic protein aggregates.
Topics & Concepts
CytosolCell biologyAutophagyChemistryeIF2Protein kinase AKinaseBiochemistryBiologyEnzymeApoptosisTranslation (biology)GeneMessenger RNAAutophagy in Disease and TherapyRNA regulation and diseaseEndoplasmic Reticulum Stress and Disease