The PPARγ agonist pioglitazone produces a female-predominant inhibition of hyperalgesia associated with surgical incision, peripheral nerve injury, and painful diabetic neuropathy
Diogo Francisco da Silva dos Santos, Renée R. Donahue, Don E. Laird, Maria Cláudia G. Oliveira, Bradley K. Taylor
Topics & Concepts
PioglitazoneMedicineAgonistPeripheral neuropathyHyperalgesiaPeripheral nerve injuryNerve injuryDiabetic neuropathyAnesthesiaPeripheralDiabetes mellitusPharmacologyInternal medicineType 2 diabetesEndocrinologySciatic nerveReceptorNociceptionPain Mechanisms and TreatmentsNeuropeptides and Animal PhysiologyAnesthesia and Pain Management