Mechanism of methyltransferase like 3 in epithelial-mesenchymal transition process, invasion, and metastasis in esophageal cancer
Xuyang Liang, Zhimei Zhang, Lu Wang, Shuxian Zhang, Ling Ren, Shouying Li, Jing Xu, Shengxiang Lv
Abstract
. Overall, METTL3 promoted m6A modification and the binding of DGCR8 to miR-20a-5p to further elevate the miR-20a-5p expression and inhibit NFIC transcription, thus promoting EMT, invasion and migration.
Topics & Concepts
Epithelial–mesenchymal transitionMetastasisMechanism (biology)Esophageal cancerCancer researchCancer metastasisCancerBiologyCell biologyChemistryMedicineInternal medicinePhysicsQuantum mechanicsRNA modifications and cancerEpigenetics and DNA MethylationCancer-related gene regulation