Drug-Loaded Mesoporous Silica Nanoparticles Enhance Antitumor Immunotherapy by Regulating MDSCs
Changlin Xu, Nida Amna, Yuchen Shi, Rong Sun, Chenhui Weng, Jiaoyu Chen, Huaxing Dai, Chao Wang
Abstract
Myeloid-derived suppressor cells (MDSCs) are recognized as major immune suppressor cells in the tumor microenvironment that may inhibit immune checkpoint blockade (ICB) therapy. Here, we developed a Stattic-loaded mesoporous silica nanoparticle (PEG-MSN-Stattic) delivery system to tumor sites to reduce the number of MDSCs in tumors. This approach is able to significantly deplete intratumoral MSDCs and thereby increase the infiltration of T lymphocytes in tumors to enhance ICB therapy. Our approach may provide a drug delivery strategy for regulating the tumor microenvironment and enhancing cancer immunotherapy efficacy.
Topics & Concepts
ImmunotherapyTumor microenvironmentMyeloid-derived Suppressor CellCancer researchDrug deliveryCancer immunotherapyImmune systemMesoporous silicaSuppressorImmune checkpointDrugBlockadeMedicineCancerChemistryPharmacologyImmunologyTumor cellsMesoporous materialInternal medicineCatalysisBiochemistryReceptorOrganic chemistryImmune cells in cancerCancer Immunotherapy and BiomarkersHistone Deacetylase Inhibitors Research