HER2-Positive Breast Cancer: Association of MRI and Clinicopathologic Features With Tumor-Infiltrating Lymphocytes
Hyo-jae Lee, Jong Eun Lee, Won Gi Jeong, So Yeon Ki, Min Ho Park, Ji Shin Lee, Yoo Kyeong Nah, Hyo Soon Lim
Abstract
. Pretreatment MRI features may serve as a useful tool for assessing TIL levels in patients with HER2-positive breast cancer and for helping to classify patients with variable clinical outcomes related to immune activity and to guide selection among neoadjuvant chemotherapy or HER2-targeted therapy or immunotherapy.
Topics & Concepts
MedicineBreast cancerTumor-infiltrating lymphocytesInternal medicineLogistic regressionHuman Epidermal Growth Factor Receptor 2Retrospective cohort studyOncologyBreast MRIProgesterone receptorPathologyHormone receptorBreast carcinomaCancerGastroenterologyImmunohistochemistryCarcinomaDuctal carcinomaStage (stratigraphy)GynecologyMultivariate analysisSubgroup analysisRadiologyBreast imagingRisk factorMagnetic resonance imagingHormoneEdemaMammary glandCancer Immunotherapy and BiomarkersRadiomics and Machine Learning in Medical ImagingBreast Cancer Treatment Studies