Protein Concentration Fluctuations in the High Expression Regime: Taylor’s Law and Its Mechanistic Origin
Alberto Stefano Sassi, Mayra Garcia-Alcala, Maximino Aldana, Yuhai Tu
Abstract
depends on strength of different noise sources, which explains its cell-to-cell variability. By using this approach to analyze our single-cell data, we found that the noise in production rate dominates the noise from cell division. The deviation from the square TL in the low expression regime can also be captured in our model by including intrinsic noise in the production rate.
Topics & Concepts
Protein expressionExpression (computer science)Statistical physicsPhysicsComputer scienceBiologyGeneticsGeneProgramming languageGene Regulatory Network AnalysisProtein Structure and DynamicsBacterial Genetics and Biotechnology