<i>In silico</i> exploration of acetic acid driven multicomponent synthesis: design, characterization, and antioxidant evaluation of spiroacridines and spiroquinolines
Subham G. Patel, Dipti B. Upadhyay, Nirajkumar V. Shah, Mehul P. Parmar, Paras J. Patel, Apoorva Malik, Rakesh K. Sharma, Hitendra M. Patel
Abstract
A simple, rapid and efficient multicomponent synthesis of spiroacridines and spiroquinolines was carried out under the influence of acetic acid and their antioxidant properties, DFT, docking and in silico ADMET and drug-likeness properties were explored.
Topics & Concepts
In silicoAcetic acidAntioxidantDocking (animal)Combinatorial chemistryChemistryBiochemical engineeringComputational biologyBiochemistryBiologyEngineeringGeneNursingMedicineMulticomponent Synthesis of HeterocyclesSynthesis and biological activityBioactive Compounds and Antitumor Agents