Secretome of senescent hepatic stellate cells favors malignant transformation from nonalcoholic steatohepatitis-fibrotic progression to hepatocellular carcinoma
Yuan Zhou, Li Zhang, Yue Ma, Li Xie, Yang Yong-yu, Jin Cheng, Hui Chen, Ying Zhou, Guangqi Song, Jia Ding, Jian Wu
Abstract
Senescent HSCs secreted a characterized protein profile favoring malignant transformation of steatotic or dysplastic hepatocytes through activating morphogenic hedgehog or oncogenic Wnt signaling pathways in the progression from NASH to malignancy.
Topics & Concepts
Nonalcoholic steatohepatitisHepatocellular carcinomaHepatic stellate cellMalignant transformationSteatohepatitisPathologyCancer researchMedicineTransformation (genetics)FibrosisInternal medicineBiologyNonalcoholic fatty liver diseaseFatty liverGeneDiseaseBiochemistryLiver physiology and pathologyLiver Disease Diagnosis and TreatmentMechanisms of cancer metastasis