Synthesis of Fully Substituted Difluoromethylpyrazoles by Cyclization of Difluoroacetohydrazonoyl Bromides with 2-Acylacetonitriles or Malononitrile
Siwei Wang, Jianzhong Zhang, Zhoubin Deng, Yuyu Lv, Danfeng Huang, Ke‐Hu Wang, JunJiao Wang, Yulai Hu
Abstract
A concise and efficient method for the construction of fully substituted difluoromethylpyrazoles is achieved by a cyclization reaction between difluoroacetohydrazonoyl bromides and 2-acylacetonitrile or malononitrile. The method features advantages such as mild reaction conditions, broad substrate scope, good product yields, and high regioselectivity.
Topics & Concepts
MalononitrileChemistryOrganic chemistryMedicinal chemistryCombinatorial chemistryCatalysisFluorine in Organic ChemistrySynthesis and Reactions of Organic CompoundsSynthesis and Biological Evaluation