Litcius/Paper detail

A lethal mouse model for evaluating vaccine-associated enhanced respiratory disease during SARS-CoV-2 infection

Naoko Iwata‐Yoshikawa, Nozomi Shiwa, Tsuyoshi Sekizuka, Kaori Sano, Akira Ainai, Takuya Hemmi, Michiyo Kataoka, Makoto Kuroda, Hideki Hasegawa, Tadaki Suzuki, Noriyo Nagata

2022Science Advances60 citationsDOIOpen Access PDF

Abstract

2-shifted immune response and insufficient neutralizing antibodies after QHmusX infection. This lethal mouse model is useful for evaluating vaccine-associated enhanced respiratory disease during SARS-CoV-2 infection and may provide new insights into the disease pathogenesis of SARS-CoV-2.

Topics & Concepts

ImmunologyImmune systemMedicineImmunopathologyVirologyRespiratory diseaseAntibodyAdjuvantPathogenesisImmunizationCoronavirusDiseaseBiologyInfectious disease (medical specialty)LungCoronavirus disease 2019 (COVID-19)PathologyInternal medicineSARS-CoV-2 and COVID-19 ResearchRespiratory viral infections researchCOVID-19 Clinical Research Studies