Dolichosin A, a coumestan isolated from Glycine tabacina, inhibits IL-1β-induced inflammation in SW982 human synovial cells and suppresses RANKL-induced osteoclastogenesis: From network pharmacology to experimental pharmacology
Yanbei Tu, Kai Wang, Lihua Tan, Bing Han, Hu Y, Hang Ding, Chengwei He
Topics & Concepts
RANKLInflammationPharmacologyPI3K/AKT/mTOR pathwayOsteoclastMAPK/ERK pathwaySignal transductionMedicineReceptorImmunologyBiologyActivator (genetics)Cell biologyInternal medicineBone Metabolism and DiseasesRheumatoid Arthritis Research and TherapiesNatural product bioactivities and synthesis