Three-component reductive conjugate addition/aldol tandem reaction enabled by nickel/photoredox dual catalysis
Hongping Zhao, Weiming Yuan
Abstract
. This dual catalytic protocol completes a traditional conjugate addition/aldol sequence that eliminates the requirement of organometallic reagents and metal-based reductants, thus providing a mild synthetic route to highly valuable β-hydroxyl carbonyl compounds with contiguous 1,2-stereocenters.
Topics & Concepts
ChemistryAldol reactionCatalysisTandemCombinatorial chemistryNickelStereocenterProtonationReagentArylConjugateUmpolungPhotoredox catalysisLewis acid catalysisCascade reactionLewis acids and basesOrganic chemistryEnantioselective synthesisPhotocatalysisIonAlkylNucleophileMathematical analysisMathematicsMaterials scienceComposite materialRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods