Iodine–TBHP mediated efficient synthesis of α-ketoamides from vinyl azides and amines under mild conditions
Swadhapriya Bhukta, Rana Chatterjee, Rambabu Dandela
Abstract
Iodine and TBHP promoted facile synthesis of α-ketoamides has been developed from vinyl azides. A variety of α-ketoamides including a Ceritinib cancer drug derivative were obtained in a high yield under mild conditions.
Topics & Concepts
Yield (engineering)IodineChemistryOrganic chemistryCombinatorial chemistryDerivative (finance)Materials scienceEconomicsMetallurgyFinancial economicsClick Chemistry and ApplicationsChemical Synthesis and AnalysisSynthesis and Catalytic Reactions