Inventing a facile method to construct<i>Bombyx mori</i>(<i>B. mori</i>) silk fibroin nanocapsules for drug delivery
Heming Zheng, Bo Duan, Zheyu Xie, Jie Wang, Mingying Yang
Abstract
cell experiments proved the biocompatibility of SF nanocapsules and their burst drug release in response to acidic environment. Furthermore, chemotherapy and photodynamic therapy proved SF nanocapsules loaded with DOX or Ce6 had significant inhibition on tumor cells. Our results suggested that this LBL technique is a facile method for polymers with negative charge to fabricate nanocapsules for antitumor drug carrier.
Topics & Concepts
NanocapsulesFibroinBiocompatibilityMaterials scienceZeta potentialDrug deliveryBombyx moriNanotechnologyPolymerCationic polymerizationChemical engineeringPolymer chemistryChemistrySILKNanoparticleComposite materialBiochemistryGeneMetallurgyEngineeringSilk-based biomaterials and applicationsPolymer Surface Interaction StudiesRNA Interference and Gene Delivery