A phase I study of the Wee1 kinase inhibitor adavosertib (AZD1775) in combination with chemoradiation in cervical, upper vaginal, and uterine cancers
Eduardo González-Ochoa, Michael Milosevic, Bradley R. Corr, James L. Abbruzzese, Eugenia Girda, Rachel W. Miller, Jennifer Croke, Helen Mackay, Yeh Chen Lee, Valerie Bowering, Janelle Ramsahai, Lisa Wang, April D'Souza, Charles A. Kunos, Amit M. Oza, Stephanie Lheureux
Topics & Concepts
MedicineCervical cancerEndometrial cancerToxicityClinical endpointInternal medicineExternal beam radiotherapyUrologyMucositisWee1CisplatinOncologyRadiation therapyClinical trialSurgeryCancerBrachytherapyChemotherapyCell cycleCyclin-dependent kinase 1Reproductive Biology and FertilityMicrotubule and mitosis dynamicsPolyomavirus and related diseases