Photoredox-catalyzed alkylarylation of activated alkenes <i>via</i> a ring-opening/Truce–Smiles rearrangement cascade
Jinhua Zhang, Hong-Jie Miao, Hong Xin, Gang Wang, Xiaoyu Yang, Xianjun Wang, Pin Gao, Xin‐Hua Duan, Li‐Na Guo
Abstract
a radical C-C bond cleavage/Truce-Smiles rearrangement cascade is developed. The protocol features mild and redox-neutral conditions, broad substrate scope and excellent functional group compatibility, providing a facile and efficient approach to the long-chain distal keto-amides with all-carbon quaternary centers at the alpha position.
Topics & Concepts
Smiles rearrangementCascadeCatalysisChemistryRing (chemistry)Photoredox catalysisCascade reactionScope (computer science)StereochemistryCombinatorial chemistryPhotochemistryComputer scienceOrganic chemistryChromatographyProgramming languagePhotocatalysisRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods