Spheroid-based skin-on-a-chip platform for the evaluation of the toxicity of small molecules and nanoparticles
Dianoosh Kalhori, Faeze Rakhshani, Yingshan Ma, Ilya Yakavets, Sina Kheiri, Ophélie Zeyons, Susanne N. Kolle, Ted Deisenroth, Liangliang Qu, Zhengkun Chen, Eugenia Kumacheva
Abstract
scores for skin irritation. Toxicity screening was extended to nanoparticles, including carbon dots, liposomes, and insecticide-loaded liposomes. This MSS-based skin-on-a-chip microfluidic platform for the safety evaluation of small molecules and nanoparticles has diverse applications in the skincare, pharmaceutical, and agriculture fields.
Topics & Concepts
Skin irritationSkin sensitizationToxicityHuman skinSensitizationNanotechnologyIrritationNanoparticleChipSpheroidChemistryMaterials scienceIn vitroComputer scienceDermatologyMedicineOrganic chemistryBiologyBiochemistryTelecommunicationsGeneticsImmunologyAnimal testing and alternativesEffects and risks of endocrine disrupting chemicalsAdvancements in Transdermal Drug Delivery