Tissue-targeted and localized AAV5-DCN and AAV5-PEDF combination gene therapy abrogates corneal fibrosis and concurrent neovascularization in rabbit eyes in vivo
Rajiv R. Mohan, Suneel Gupta, Rajnish Kumar, Nishant R. Sinha, James Landreneau, Prashant R. Sinha, Ashish Tandon, Shyam S. Chaurasia, Nathan P. Hesemann
Topics & Concepts
PEDFIn vivoFibrosisNeovascularizationChoroidal neovascularizationGenetic enhancementMedicinePathologyCancer researchOphthalmologyAngiogenesisBiologyGeneMacular degenerationBiochemistryBiotechnologyCorneal Surgery and TreatmentsVirus-based gene therapy researchProteoglycans and glycosaminoglycans research