SuFExable Isocyanides for Ugi Reaction: Synthesis of Sulfonyl Fluoro Peptides
Shuheng Xu, Sunliang Cui
Abstract
Herein, the sulfonyl fluoro isocyanides were first developed as a new type of SuFExable synthon, and they are used as building blocks in the Ugi reaction (U-4CR). The Ugi reaction was established and the substrate scope was investigated, and various sulfonyl fluoro α-amino amides and peptides could be reached in a one-step synthesis. Therefore, this protocol opens a new vision for SuFExable building blocks and click chemistry, and it also provides a distinct approach to sulfonyl fluoro peptides.
Topics & Concepts
SulfonylChemistrySynthonUgi reactionCombinatorial chemistrySubstrate (aquarium)StereochemistryIsocyanideOrganic chemistryGeologyOceanographyAlkylClick Chemistry and ApplicationsChemical Synthesis and AnalysisMulticomponent Synthesis of Heterocycles