Massively parallel phenotyping of coding variants in cancer with Perturb-seq
Oana Ursu, James T. Neal, Emily Shea, Pratiksha I. Thakore, Livnat Jerby-Arnon, Lan Nguyen, Danielle Dionne, Celeste Diaz, Julia Bauman, Mariam Mounir Mosaad, Christian Fagre, April Lo, Maria McSharry, Andrew O. Giacomelli, Seav Huong Ly, Orit Rozenblatt-Rosen, William C. Hahn, Andrew J. Aguirre, Alice H. Berger, Aviv Regev, Jesse S. Boehm
Topics & Concepts
KRASComputational biologyPhenotypeBiologyGenomeCancer genome sequencingMassive parallel sequencingProteogenomicsGeneticsCategorizationCancerCoding (social sciences)GenomicsDiseaseHuman genomeGeneRNASomatic cellGenetic variantsCoding regionInferenceLung cancerMutationWhole genome sequencingComputer scienceDNA sequencingFunction (biology)Cancer Genomics and DiagnosticsGenomics and Rare DiseasesBioinformatics and Genomic Networks