Modulation of CD47-SIRPα innate immune checkpoint axis with Fc-function detuned anti-CD47 therapeutic antibody
Rama Krishna Narla, Hardik Modi, Daniel E. Bauer, Mahan Abbasian, Jim Leisten, Joseph R. Piccotti, Stephan Kopytek, Brendan P. Eckelman, Quinn L. Deveraux, John C. Timmer, Dan Zhu, Lilly Wong, Laure Escoubet, Heather K. Raymon, Kandasamy Hariharan
Topics & Concepts
CD47Cancer researchAntibodyImmune systemPhagocytosisImmunologyImmune checkpointAntibody-dependent cell-mediated cytotoxicityBiologyChemistryMonoclonal antibodyImmunotherapyPhagocytosis and Immune RegulationComplement system in diseasesErythrocyte Function and Pathophysiology