Coronary Computed Tomography Angiography–derived Fractional Flow Reserve
Long Jiang Zhang, Chunxiang Tang, Pengpeng Xu, Bangjun Guo, Fan Zhou, Yi Xue, Jiayin Zhang, Minwen Zheng, Lei Xu, Yang Hou, Bin Lü, Youmin Guo, Jingliang Cheng, Changhong Liang, Bin Song, Huimao Zhang, Nan Hong, Peijun Wang, Min Chen, Ke Xu, Shiyuan Liu, Zhengyu Jin, Guangming Lu, on behalf of Chinese Society of Radiology
Abstract
Invasive fractional flow reserve (FFR) measured by a pressure wire is a reference standard for evaluating functional stenosis in coronary artery disease. Coronary computed tomography angiography-derived fractional flow reserve (CT-FFR) uses advanced computational analysis methods to noninvasively obtain FFR results from a single conventional coronary computed tomography angiography data to evaluate the hemodynamic significance of coronary artery disease. More and more evidence has found good correlation between the results of noninvasive CT-FFR and invasive FFR. CT-FFR has proven its potential in optimizing patient management, improving risk stratification and prognosis, and reducing total health care costs. However, there is still a lack of standardized interpretation of CT-FFR technology in real-world clinical settings. This expert consensus introduces the principle, workflow, and interpretation of CT-FFR; summarizes the state-of-the-art application of CT-FFR; and provides suggestions and recommendations for the application of CT-FFR with the aim of promoting the standardized application of CT-FFR in clinical practice.