<i>In Vitro</i> Antifungal Combination of Terbinafine with Itraconazole against Isolates of <i>Trichophyton</i> Species
Anne-Laure Bidaud, Patrick Schwarz, Anuradha Chowdhary, Eric Dannaoui
Abstract
Terbinafine is used as the first-line therapy for dermatophytosis, but the incidence of terbinafine resistance is increasing. A combination of terbinafine with itraconazole was tested using the checkerboard method based on the EUCAST methodology for antifungal susceptibility testing against 9 terbinafine-susceptible and 7 terbinafine-resistant clinical isolates of Trichophyton spp. from India.
Topics & Concepts
TerbinafineItraconazoleAntifungalMicrobiologyBiologyMinimum inhibitory concentrationPharmacologyCheckerboardAntifungal drugsMedicineMycosisFungi imperfectiDrug resistanceCombination therapyTraditional medicineIncidence (geometry)FluconazoleNail Diseases and TreatmentsAntifungal resistance and susceptibilityDermatological diseases and infestations