Neuroprotection in Acute Ischemic Stroke: A Brief Review
Alastair M. Buchan, David M. Pelz
2021Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques22 citationsDOI
Abstract
The goal of effective neuroprotection in acute ischemic stroke remains elusive. Despite decades of experimental preclinical and clinical experience with innumerable agents, no strategy has proven to be beneficial in humans. As endovascular therapies mature and approach the limits of speed and efficacy, neuroprotection will become the next frontier of acute stroke care. This review will briefly summarize the history, preclinical and clinical triumphs and failures, and future directions of cerebral neuroprotection.
Topics & Concepts
NeuroprotectionMedicineStroke (engine)Acute strokeIntensive care medicineNeurosciencePharmacologyInternal medicinePsychologyMechanical engineeringEngineeringTissue plasminogen activatorAcute Ischemic Stroke ManagementNeurological Disorders and TreatmentsNeurological Disease Mechanisms and Treatments