A heterologous expression platform in <i>Aspergillus nidulans</i> for the elucidation of cryptic secondary metabolism biosynthetic gene clusters: discovery of the <i>Aspergillus fumigatus</i> sartorypyrone biosynthetic pathway
Shu-Yi Lin, C. Elizabeth Oakley, Cory B. Jenkinson, Yi‐Ming Chiang, Ching‐Kuo Lee, Christopher G. Jones, Paul M. Seidler, Hosea M. Nelson, Richard B. Todd, Clay C. C. Wang, Berl R. Oakley
Abstract
Secondary metabolites are important for the pathogenesis of the fungus Aspergillus fumigatus which causes lethal Aspergillosis. Expressing groups of A. fumigatus genes in the fungus Aspergillus nidulans reveals new A. fumigatus secondary metabolites.
Topics & Concepts
Aspergillus fumigatusAspergillus nidulansAspergillusBiologyFungusMicrobiologyAspergillosisSecondary metabolismGeneHeterologousBiosynthesisBiochemistryImmunologyBotanyMutantMicrobial Natural Products and BiosynthesisFungal Biology and ApplicationsAntifungal resistance and susceptibility