CDK Family PROTAC Profiling Reveals Distinct Kinetic Responses and Cell Cycle–Dependent Degradation of CDK2
Kristin M. Riching, Marie K. Schwinn, James D. Vasta, Matthew B. Robers, Thomas Machleidt, Marjeta Urh, Danette L. Daniels
Topics & Concepts
Cyclin-dependent kinaseCyclin-dependent kinase 2Cyclin-dependent kinase 6Ubiquitin ligaseCell biologyCell cycleProtein degradationCDK inhibitorBiologyProteolysisKinaseChemistryBiochemistryUbiquitinCellProtein kinase AEnzymeGeneProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysMultiple Myeloma Research and Treatments