Nanotechnological approaches for the targeted delivery of CRISPR-Cas systems for genomic modifications, biomolecular sensing, and precision medicine
Mirza Muhammad Faran Ashraf Baig, Wai Tong Chien, Sek Ying Chair
Abstract
, Cas9, Cas12, Cas13, and Cas14 proteins and single-guide RNAs (sgRNAs)) maximized gene targeting and improved therapeutic outcomes while achieving up to 90% efficiency compared with common/trivial delivery methods.
Topics & Concepts
CRISPRGene deliveryComputational biologyNanotechnologyGenome editingCas9Computer scienceGeneBiologyGenetic enhancementMaterials scienceGeneticsCRISPR and Genetic EngineeringRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniques