Ultrasensitive detection of gastric cancer biomarkers <i>via</i> a frequency shift-based SERS microfluidic chip
Yong Huang, Zhengqing Liu, Xiaogang Qin, Jia Liu, Yan Yang, Wei Wei
Abstract
for VEGF. During the detection process, only one step of sample addition is involved, which eliminates the multiple reaction step-induced nonspecific adsorption and significantly increases the convenience and specificity. In addition, serum samples from GC patients and healthy subjects were tested and the results were in good agreement with the current gold-standard method ELISA, suggesting the potential application of the SERS microfluidic chip in clinical settings for early diagnosis and prognosis of GC.
Topics & Concepts
Detection limitCarcinoembryonic antigenFrequency shiftMicrofluidicsMicrofluidic chipRaman scatteringChemistryChromatographyChipCancer biomarkersRaman spectroscopyBiomarkerNanotechnologyCancerAnalytical Chemistry (journal)Materials scienceMedicineInternal medicineBiochemistryComputer scienceOpticsTelecommunicationsPhysicsAdvanced Biosensing Techniques and ApplicationsBiosensors and Analytical DetectionInnovative Microfluidic and Catalytic Techniques Innovation