Transition Metal Catalyzed Enantioselective C(sp<sup>2</sup>)–H Bond Functionalization
Tapas Kumar Achar, Sudip Maiti, Sadhan Jana, Debabrata Maiti
Abstract
Direct catalytic transformation of C–H bonds to new functionalities has provided a powerful strategy to synthesize complex molecular scaffolds in a straightforward way. Unstinting efforts of the synthetic community have helped to overcome the long-standing major challenge of regioselectivity by introducing the directing group concept. However, the full potential of the strategy cannot be realized unless the activated C–H bonds are stereochemically controlled. The enantioselective C–H bond functionalization could provide an imperative tool for a sustainable way of synthesizing chiral complex molecular scaffolds. Despite the intrinsic challenges in achieving stereocontrol, the synthetic community has developed different tools in order to achieve stereoselective C–H bond functionalization. In this review, we discuss the remarkable recent advances in the emerging area of enantioselective C(sp2)–H bond functionalization to highlight the challenges and opportunities, emphasizing the different techniques developed so far.