Discovery of a novel selective water-soluble SMAD3 inhibitor as an antitumor agent
Nannan Wu, Guang‐Yu Lian, Jingyi Sheng, Dan Wu, Xi‐Yong Yu, Huiyao Lan, Wenhui Hu, Zhongjin Yang
Topics & Concepts
ChemistryIn vivoWater solubleStructure–activity relationshipSolubilityIn vitroLead compoundDrug discoveryBiochemistryComputational biologyPharmacologyCombinatorial chemistryBiotechnologyOrganic chemistryBiologyMedicineTGF-β signaling in diseasesPancreatic and Hepatic Oncology ResearchMetabolism, Diabetes, and Cancer