A novel NEDD4L-TXNIP-CHOP axis in the pathogenesis of nonalcoholic steatohepatitis
Qian Guo, Mingyang Xin, Qingchun Lu, Dechun Feng, Vicky K. Yang, Lee F. Peng, Kelly A. Whelan, Wen-Hui Hu, Sheng Wu, Xiaofeng Yang, Hong Wang, Brad S. Rothberg, Ana M. Gamero, Glenn S. Gerhard, Bin Gao, Ling Yang
Abstract
Our study revealed a pathogenic role of hepatic TXNIP in NASH and identified a novel NEDD4L-TXNIP-CHOP axis in the pathogenesis of NASH.
Topics & Concepts
TXNIPThioredoxin-Interacting ProteinCancer researchPathogenesisBiologyCHOPGene knockdownApoptosisCell biologyImmunologyEndocrinologyEndoplasmic reticulumOxidative stressBiochemistryThioredoxinEndoplasmic Reticulum Stress and DiseaseRedox biology and oxidative stressHeat shock proteins research