Engraftment of strictly anaerobic oxygen-sensitive bacteria in irritable bowel syndrome patients following fecal microbiota transplantation does not improve symptoms
Patrick Denis Browne, Frederik Cold, Andreas Munk Petersen, Sofie Ingdam Halkjær, Alice Højer Christensen, Stig Günther, Lars Hestbjerg Hansen
Abstract
and increased microbial diversity, particularly in patients with low initial diversity. FMT recipients lost ASVs after treatment, which was seen to a much lesser extent in the placebo group. No ASVs increased to a greater extent between FMT responders and non-responders following treatment. Major long-term changes, lasting for at least 6 months, in the gut microbiomes of IBS patients are seen following treatment with FMT capsules. None of these changes correlated with clinical improvement. The relationship between the microbiome and the etiology of IBS still remains unsolved.
Topics & Concepts
Irritable bowel syndromeMicrobiomeDysbiosisPrevotellaBacteroidesBiologyAnaerobic exerciseTransplantationProbioticPlaceboFecesInternal medicineGastroenterologyBacteroides fragilisAnaerobic bacteriaMedicinePhysiologyMicrobiologyAntibioticsBacteriaPathologyBioinformaticsGeneticsAlternative medicineGastrointestinal motility and disordersGut microbiota and healthClostridium difficile and Clostridium perfringens research