Selective functionalization of C(sp<sup>3</sup>)–H bonds: catalytic chlorination and bromination by Iron<sup>III</sup>-acacen-halide under ambient condition
Chang Shen, Wasihun Menberu Dagnaw, Ching Wai Fong, Kai‐Chung Lau, Cheuk‐Fai Chow
Abstract
(acacen)(oxo)X] species (X = Cl or Br), (ii) hydrogen-atom transfer, (iii) halogen atom rebound, and (iv) regeneration of 1III-Cl or 1III-Br. TFA played a significant role in (i) forming the high-valent iron-oxo intermediate and (ii) generating the reaction selectivity.
Topics & Concepts
HalogenationChemistryCatalysisTrifluoroacetic acidHalogenMedicinal chemistrySelectivityOrganic chemistryAlkylMetal-Catalyzed Oxygenation MechanismsVanadium and Halogenation ChemistryOxidative Organic Chemistry Reactions