Access to Amides and Lactams via Pyridotriazole as a Transformable Directing Group
Yuting Chen, Zhiyang Li, Yanning Xu, Tianle Huang, Li Hai, Ruifang Nie, Yong Wu
Abstract
Amide and lactam frameworks were synthesized via an efficient two-step strategy. In this protocol, pyridotriazoles were first treated with isocyanates to form the corresponding amides, which were found to be sufficiently reactive to undergo subsequent intramolecular N-H insertion in the absence of any additional reagents or catalysts.
Topics & Concepts
Intramolecular forceAmideReagentCombinatorial chemistryChemistryCatalysisLactamGroup (periodic table)StereochemistryOrganic chemistryCatalytic C–H Functionalization MethodsChemical Synthesis and AnalysisAsymmetric Hydrogenation and Catalysis