Litcius/Paper detail

Exploiting the tolerant region I of the non-nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket. Part 2: Discovery of diarylpyrimidine derivatives as potent HIV-1 NNRTIs with high Fsp3 values and favorable drug-like properties

Xiangyi Jiang, Boshi Huang, Fisayo A. Olotu, Jing Li, Dongwei Kang, Zhao Wang, Erik De Clercq, Mahmoud E. S. Soliman, Christophe Pannecouque, Xinyong Liu, Peng Zhan

2020European Journal of Medicinal Chemistry26 citationsDOIOpen Access PDF

Topics & Concepts

EtravirineChemistryReverse transcriptaseReverse-transcriptase inhibitorNucleoside Reverse Transcriptase InhibitorEC50StereochemistryDrug discoveryDocking (animal)CytotoxicityNucleosideRilpivirineHuman immunodeficiency virus (HIV)VirologyIn vitroBiochemistryViral loadRNABiologyAntiretroviral therapyGeneNursingMedicineHIV/AIDS drug development and treatmentHIV Research and TreatmentDNA and Nucleic Acid Chemistry