Enantioselective <scp>NiH‐Catalyzed</scp> Reductive Hydrofunctionalization of Alkenes

Abstract

Comprehensive Summary Enantioselective NiH‐catalyzed reductive hydrofunctionalization of olefins has attracted much attention in recent years. Using simple chiral ligands, a wide array of functionalized olefins and electrophiles can undergo diverse transformations to afford hydrofunctionalized products, regio‐ and enantioselectively. These processes avoid the prior preparation of organometallic reagents, and can construct a stereogenic center at a carbon originating either from the olefin or from the electrophile. This review discusses the background, major progress and mechanistic investigations in this reaction.

Topics & Concepts