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Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy

Feifei Zhang, Ryan D. Chow, Emily He, Chuanpeng Dong, Xin Shan, Daniyal Mirza, Yanzhi Feng, Xiaolong Tian, Nipun Verma, Medha Majety, Yueqi Zhang, Guangchuan Wang, Sidi Chen

2025Nature Biotechnology17 citationsDOI

Topics & Concepts

Cancer immunotherapyImmunotherapyGeneBiologyCancerComputational biologyImmunologyCancer researchImmune systemGeneticsCAR-T cell therapy researchCancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses
Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy | Litcius