Light-responsive hyaluronic acid nanomicelles co-loaded with an IDO inhibitor focus targeted photoimmunotherapy against “immune cold” cancer
Chunhui Wu, Jiming Xu, Zhengxin Xie, Honglin Huang, Ningxi Li, Xiaodan Wei, Tingting Li, Hong Yang, Shun Li, Xiang Qin, Yiyao Liu
Abstract
. Meanwhile, the IDO1-mediated immunosuppression was effectively reprogrammed to an immunostimulatory phenotype, which was accompanied by an enhanced cytotoxic T cell response as well as reduced Treg infiltration in tumour bed. Ultimately, the 4T1 tumour was synergistically suppressed by NLG919@HA-Ce6 due to the outcome of focused PDT, obvious ICD post PDT and IDO1 blockade. This study suggests the promise of NLG919@HA-Ce6 as an alternative simple, stimulative and targeted nanoagent to enable the whole-body photo-immune therapy against "immune cold" cancer.
Topics & Concepts
Immunogenic cell deathImmune systemCancer researchPhotodynamic therapyTumor microenvironmentImmunotherapyCancer immunotherapyCancer cellImmune checkpointPhotosensitizerCancerImmunologyMedicineChemistryInternal medicineOrganic chemistryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesCancer Immunotherapy and Biomarkers