Predictors of Clostridioides difficile Infection-Related Complications and Treatment Patterns among Nucleic Acid Amplification Test-Positive/Toxin Enzyme Immunoassay-Negative Patients
Ryan Miller, Jose A. Morillas, Kyle D. Brizendine, Thomas G. Fraser
Abstract
The addition of toxin enzyme immunoassay (EIA) to nucleic acid amplification tests, including PCR, creates challenges in the diagnosis and management of Clostridioides difficile infection (CDI). There are limited data in large cohorts, with discordant results, that is, PCR-positive/EIA-negative (PCR + /EIA − ) results. We conducted a retrospective cohort study on all PCR + /EIA − adult inpatients and assessed CDI-related complications and clinical failure.
Topics & Concepts
ClostridioidesImmunoassayNucleic Acid Amplification TestsPolymerase chain reactionNucleic acidToxinBiologyInternal medicineMicrobiologyMedicineVirologyImmunologyGeneGeneticsAntibodyChlamydia trachomatisClostridium difficile and Clostridium perfringens researchViral gastroenteritis research and epidemiologyMicroscopic Colitis