Porphyrins as Chelating Agents for Molecular Imaging in Nuclear Medicine
Krystyna Pyrzyńska, Krzysztof Kilian, Mateusz Pęgier
Abstract
Porphyrin ligands, showing a significant affinity for cancer cells, also have the ability to chelate metallic radioisotopes to form potential diagnostic radiopharmaceuticals. They can be applied in single-photon emission computed tomography (SPECT) and positron emission tomography (PET) to evaluate metabolic changes in the human body for tumor diagnostics. The aim of this paper is to present a short overview of the main metallic radionuclides complexed by porphyrin ligands and used in these techniques. These chelation reactions are discussed in terms of the complexation conditions and kinetics and the complex stability.
Topics & Concepts
ChelationPositron emission tomographyPorphyrinEmission computed tomographyChemistryMolecular imagingSingle-photon emission computed tomographyRadiochemistryCombinatorial chemistryMetalNuclear medicinePhotochemistryMedicineOrganic chemistryBiologyBiotechnologyIn vivoRadiopharmaceutical Chemistry and ApplicationsMedical Imaging Techniques and ApplicationsLanthanide and Transition Metal Complexes