PLGA microspheres carrying miR-20a-5p improved intestinal epithelial barrier function in patients with Crohn’s disease through STAT3-mediated inhibition of Th17 differentiation
Honggang Wang, Hailin Xing, Yong Xia, Yaxing Zhou, Jiaxin Zhou, Lijun Li, Wenxuan Tao, Qinghong Liu, Yong Wang, Jie Zhao, Yin Yuan, Changhe Zhang, Weiming Zhu
Topics & Concepts
microRNADownregulation and upregulationSTAT3InflammationBarrier functionPLGAColitisSignal transductionCancer researchInflammatory bowel diseaseBiologyMicroarray analysis techniquesCrohn's diseaseCell biologyImmunologyGene expressionMedicineDiseaseGenePathologyBiochemistryIn vitroInflammatory Bowel DiseaseMicroRNA in disease regulationBarrier Structure and Function Studies