Asymmetric Transfer Hydrogenation of Ketones Improved by PNN–Manganese Complexes
Yi‐Chang Su, Zhifeng Ma, Jingyao Wang, Libin Li, Xiuli Yan, Ning Ma, Qingbin Liu, Gregory A. Solan, Zheng Wang
Abstract
Chiral manganese(I) complexes that contain carbocyclic-fused 8-amino-5,6,7,8-tetrahydroquinolinyl groups that are appended with distinct para -R substituents have proven to be effective catalysts in the asymmetric transfer hydrogenation (ATH) of a wide range of ketones (48 examples). Notably, Mn2 proved to be the most productive catalyst, allowing an outstanding turnover number of 8300 with catalyst loadings as low as 0.01 mol %. Furthermore, this catalytic protocol shows considerable promise for applications in the synthesis of chiral drugs such as Lusutrombopag.
Topics & Concepts
ManganeseCatalysisTransfer hydrogenationCombinatorial chemistryChemistryOrganic chemistryRutheniumAsymmetric Hydrogenation and CatalysisCatalysis for Biomass ConversionSurface Chemistry and Catalysis