Chromogranin A-derived peptide CGA47-66 protects against septic brain injury by reducing blood-brain barrier damage through the PI3K/AKT pathway
FengLin Wang, Yan Zeng, Xian Liu, JiaJun Cao, Shengnan Kang, WuShuang Zhou, Xiaoying Chen, Jinglun Liu, Dan Zhang
Topics & Concepts
PI3K/AKT/mTOR pathwayLY294002Blood–brain barrierProtein kinase BTight junctionSepsisPharmacologyLipopolysaccharideChromogranin AMedicinePeptideStimulationChemistrySignal transductionCell biologyBiologyCentral nervous systemImmunologyInternal medicineBiochemistryImmunohistochemistryS100 Proteins and AnnexinsBarrier Structure and Function StudiesNeuroinflammation and Neurodegeneration Mechanisms