Catalytic Domain Plasticity of MKK7 Reveals Structural Mechanisms of Allosteric Activation and Diverse Targeting Opportunities
Martin Schröder, Li Tan, Jinhua Wang, Yanke Liang, Nathanael S. Gray, Stefan Knapp, A. Chaikuad
Topics & Concepts
Allosteric regulationRegulatorTransferaseChemistryProtein kinase domainHelix (gastropod)KinaseStructural biologyCell biologyEnzymeComputational biologyBiochemistryBiologyGeneSnailEcologyMutantMelanoma and MAPK PathwaysCancer Mechanisms and TherapyProtein Tyrosine Phosphatases