Glutamine metabolism controls amphiregulin-facilitated chemoresistance to cisplatin in human chondrosarcoma
Yuying Wu, Yat‐Yin Law, Yu-Wen Huang, Nguyen Bao Tran, Chih‐Yang Lin, Chao-Yang Lai, Yuan‐Li Huang, Chun‐Hao Tsai, Chih‐Yuan Ko, Ming‐Chih Chou, Wei‐Chien Huang, Fang‐Ju Cheng, Yi‐Chin Fong, Chih‐Hsin Tang
Abstract
. These results indicate that AR and glutamine metabolism are worth pursuing as therapeutic targets in dealing with cisplatin-resistant human chondrosarcoma.
Topics & Concepts
ChondrosarcomaAmphiregulinGlutamineCancer researchCisplatinGlutaminaseBiologyChemistryEpidermal growth factor receptorPharmacologyBiochemistryInternal medicineReceptorMedicinePathologyChemotherapyAmino acidSarcoma Diagnosis and TreatmentBone Tumor Diagnosis and TreatmentsCholangiocarcinoma and Gallbladder Cancer Studies