Rhodium/copper-cocatalyzed coupling-cyclization of <i>o</i>-alkenyl arylisocyanides with vinyl azides: one-pot synthesis of α-carbolines
Ming Yang, Xianghe Meng, Zhuo Wang, Yue Gong, Yu‐Long Zhao
Abstract
A novel rhodium/copper-cocatalyzed coupling–cyclization reaction of <italic>o</italic>-alkenyl arylisocyanides with vinyl azides has been developed. The reaction provides a new route to α-carbolines by the formation of two C–C bonds, one C–N bond and two aromatic rings in a single step.
Topics & Concepts
ChemistryRhodiumCopperCoupling reactionPolymer chemistryCoupling (piping)Medicinal chemistryOrganic chemistryCombinatorial chemistryCatalysisEngineeringMechanical engineeringCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsCatalytic Alkyne Reactions