Equilibria between conformational states of the Ras oncogene protein revealed by high pressure crystallography
Éric Girard, Pedro E. M. Lopes, Michael Spoerner, Anne‐Claire Dhaussy, T. Prangé, Hans Robert Kalbitzer, N. Colloc’h
Abstract
phase transitions induced by pressure open the possibility to finely explore the structural determinants related to switching between Ras allosteric sub-states without any mutations nor exogenous partners.
Topics & Concepts
CrystallographyHigh pressureCrystal structureChemistryThermodynamicsPhysicsEnzyme Structure and FunctionProtein Structure and DynamicsProtein Kinase Regulation and GTPase Signaling