Palladium-Catalyzed Regioselective Carbonylation of 2-Trifluoromethyl-1,3-enynes to Multisubstituted Conjugated Dienes
Chang‐Sheng Kuai, Bing‐Hong Teng, Da-Lie An, Yingying Zhao, Xiao‐Feng Wu
Abstract
In this communication, a palladium-catalyzed regio- and stereoselective carbonylation of 2-trifluoromethyl-1,3-enynes to afford multisubstituted conjugated dienes has been realized. This protocol features excellent regio- and exclusive ( E )-stereoselectivity and a broad substrate scope with both amines and alcohols as the suitable reaction partners and has shown promising functional group tolerance.
Topics & Concepts
ChemistryStereoselectivityRegioselectivityConjugated systemPalladiumTrifluoromethylCarbonylationCatalysisSubstrate (aquarium)Organic chemistryCombinatorial chemistryMedicinal chemistryGeologyCarbon monoxideAlkylPolymerOceanographyFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions