Single-cell peripheral immunoprofiling of Alzheimer’s and Parkinson’s diseases
Thanaphong Phongpreecha, Rosemary Fernandez, Dunja Mrdjen, Anthony Culos, Chandresh R. Gajera, Adam M. Wawro, Natalie Stanley, Brice Gaudillière, Kathleen L. Poston, Nima Aghaeepour, Thomas J. Montine
Abstract
is associated with a decreased risk of AD. Together, these data suggest enhanced PLCγ2 activity as a potential new therapeutic target for AD with a readily accessible pharmacodynamic biomarker.
Topics & Concepts
PeripheralDiseaseImmune systemMedicineAlzheimer's diseaseNeuroscienceParkinson's diseaseImmunologyPathologyBiologyInternal medicineNeuroinflammation and Neurodegeneration MechanismsTryptophan and brain disordersAlzheimer's disease research and treatments